Янкопулос, Джордж Д.,Пападопулос, Николас Дж.,Мерфи, Эндрю Дж.,Шталь, Нейл
申请号：
EA201590370
公开号：
EA201590370A1
申请日:
2013.08.12
申请国别(地区):
EA
年份:
2015
代理人:
摘要：
the present invention relates to antibodies and their \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u0441\u0432\u044f\u0437\u044b\u0432\u0430\u044e\u0449\u0438\u043c fragments specifically bind \u043a\u043e\u043d\u0432\u0435\u0440\u0442\u0430\u0437\u0443 \u043f\u0440\u043e\u0431\u0435\u043b\u043a\u043e\u0432 \u0441\u0443\u0431\u0442\u0438\u043b\u0438\u0437\u0438\u043d\u043e\u0432\u043e\u0433\u043e \/ \u043a\u0435\u043a\u0441\u0438\u043d\u043e\u0432\u043e the type 9 (PCSK9) with higher \u0430\u0444\u0444\u0438\u043d\u043d\u043e\u0441\u0442\u044c\u044e at neutral ph values than at acidic ph values.the antibodies described in the application, may have one or more modifications of amino acids compared with antibodies that do not possess the characteristics of ph dependent \u0441\u0432\u044f\u0437\u044b\u0432 anija parish. for example, the invention relates to antibodies to the PCSK9 that have one or more substitutions in the histidine in one or more areas for complementarity them.the antibodies described in the application, with the properties of ph dependent binding, remain in the bloodstream and active reduction of cholesterol for longer periods of time the animals compared with antibodies to PCSK9, which show characteristics of ph dependent binding.thus, the antibodies described in the application, is suitable for the treatment of diseases and disorders associated with elevated levels of cholesterol HDL where antibodies described in the application, you can be patient in lower dose and \/ or with a lower frequency of dosing compared with antibodies, which do not show the characteristics of ph dependent st. \u044f\u0437\u044b\u0432\u0430\u043d\u0438\u044f.Настоящее изобретение относится к антителам и их антигенсвязывающим фрагментам, которые специфически связывают конвертазу пробелков субтилизинового/кексинового типа 9 (PCSK9) с более высокой аффинностью при нейтральных значениях рН, чем при кислых значениях рН. Антитела, описанные в заявке, могут иметь одно или нескольк
