A method and projectile to combat nests of harmful insects comprising: - the provision of a mould with cavities shaped like a projectile; - the pouring into the mould cavities of a liquid pesticide suitable for the type of insects to be combated; - the freezing of the liquid pesticide poured into the mould cavities; - the removal of the pesticide frozen projectiles from the mould cavities; - the firing of the pesticide frozen projectiles into the inside of the nest and - the distribution of the liquid pesticide inside the nest during the gradual thawing of the projectiles at room temperature.