Carl Gustav Figdor;Teunis Bernard Herman Geijtenbeek;Yvette Van Kooyk;Ruurd Torensma
发明人:
Carl Gustav Figdor,Teunis Bernard Herman Geijtenbeek,Yvette Van Kooyk,Ruurd Torensma
申请号：
US10625202
公开号：
US08105599B2
申请日:
2003.07.23
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to the use of a compound that binds to a C-type lectin on the surface of a dendritic cell, in the preparation of a composition for modulating, in particular reducing, the immune response in an animal, in particular a human or another mammal. The composition in particular modulates the interactions between a dendritic cell and a T-cell, more specifically between a C-type lectin on the surface of a dendritic cell and an ICAM receptor on the surface of a T-cell. The compositions can be used for preventing/inhibiting immune responses to specific antigens, for inducing tolerance, for immunotherapy, for immunosuppression, for the treatment of autoimmune diseases, and the treatment of allergy. The compound that binds to a C-type lectin is preferably chosen from mannose, fucose, plant lectins, antibiotics, sugars, proteins or antibodies against C-type lectins. The invention also relates to such antibodies.
