Yissum Research Development Company of The Hebrew University of Jerusalem
发明人:
Yedgar, Saul
申请号：
AU2011213739
公开号：
AU2011213739B2
申请日:
2011.08.18
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
#$%^&*AU2011213739B220131121.pdf#####Abstract Use of a compound represented by the structure of the general formula (A): L-Z-Y--X - - n 5 (A) wherein L is a lipid or a phospholipid Z is either nothing, ethanolamine, serine, inositol, choline, or glycerol Y is either nothing or a spacer group ranging in length from 2 to 30 atoms 10 X is a physiologically acceptable monomer, dimer, oligomer, or polymer and n is a number from I to 1000 for the preparation of a composition to treat asthma. 127 2783a971 (GHMatters) P75827.AU.11/22 Fig. 1.1: Inhibition of endothelin-1 (ET)-induced contraction of rat tracheal rings by Lipid-conjugates. A: Contraction of rat trachea by Endothelin-1. 100 75 50 25 0 -9 -8 -7 -6 -5 -4 Log[ET] B: Effect of HYPE on ETinduced contraction of rat 100 trachea. 80 .8 60 A 40 0 U 20 0, 0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 HYPE [M]
