Gary Davidson,Pavel Levkin,Linxian Li,Yi Su,David Zahner
申请号：
US14124468
公开号：
US09511024B2
申请日:
2012.05.15
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention provides new amino lipids and a convenient method for synthesizing these compounds. These (cationic) amino lipids have good properties as transfection agents. The method is an economic versatile two step synthesis allowing the preparation of various amino lipids thus leading to the assembly of a combinatorial library of transfection agents. Moreover, the present invention provides lipid particles (liposomes) containing said amino lipids and their use for delivering bioactive agents into cells. The invention encompasses also the use of lipid particles containing the cationic amino lipids as medicament.
