Roberto Adamo,Martin Allen,Francesco Berti,Elisa Danieli,Qi-Ying Hu
申请号：
US14131150
公开号：
US09149541B2
申请日:
2012.07.05
申请国别(地区):
US
年份:
2015
代理人:
摘要：
A process is provided for preparing a conjugate of Formula (I-A) or (I) comprising a polypeptide containing n number of tyrosine units, where n is an integer greater than or equal to 1, dispersed within the amino acid chainhaving and amino terminus end (A1) and an acid terminus end (A2) of the protein or polypeptide and having a weight average molecular weight equal to or greater than 10,000 Daltons (10 kDa), wherein the conjugate comprises a number m of tyrosine conjugates (modified tyrosine residues) as depicted in Formula (I-A) or (I), where m is at least one and is less than or equal to n:where X, Lg, L and R are as defined herein.
