БЕРТОН Скотт А.,ФРЕДЕРИКСОН Франклин Л.,ХАНСЕН Кристен Дж.,СИММЕРС Райан Патрик,ФЕНН Перси Т.,МОУКЛИ Крэйг С.
申请号：
RU2011120269
公开号：
RU2011120269A
申请日:
2009.11.17
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. A method for the rapid and large volumes of intradermal administration of liquid with minimum pain, comprising the steps of: superposed array containing from 10 to 30 hollow microneedles length greater than 100 microns, the patient's skin with the depth of penetration of less than 1 mm, the average distance between adjacent microneedles in the array is an average of at least 1.5 mm, is introduced through the hollow microneedle of more than 200 l of liquid at a rate exceeding 20 .mu.l / min.2. A method according to claim 1, characterized in that the array comprises from 13 to 20 mikroigl.3. A method according to claim 1 or 2, characterized in that the hollow microneedles have an average channel cross-sectional area value of from 20 to 50 mkm.4. A method according to claim 1 or 2, characterized in that the length of the microneedles is between 500 and 750 mkm.5. A method according to claim 1 or 2, characterized in that the density of the microneedles in the array is from 30 to 50 microneedles / sm.6. A method according to claim 1 or 2, characterized in that the microneedles are administered through at least 750 .mu.l zhidkosti.7. A method according to claim 1 or 2, characterized in that the fluid is introduced through the hollow microneedles at a rate of at least 400 l / Min.8. A method according to claim 1 or 2, characterized in that the counterpressure liquid when introduced is not more than 25 lb / dyuym.9. A method according to claim 8, characterized in that the back pressure when administered liquid was maintained at 20 lbs / dyuym.10. A method according to claim 1 or 2, characterized in that each of the microneedles has an outlet disposed at its side stenke.11. A method according to claim 1 or 2, characterized in that the microneedles come into the dermis to a depth of 100 microns to 400 mkm.12. A method according to claim 1 or 2, characterized in that the microneedles are arranged at an average distance of at least 2 mm from each other.1. Способ быстрого и в
