A method of using sequence of antagomiR for developing medicine for inhibiting oral cancer cells from spreading is provided with the steps of combining a sequence of antagomiR with active ingredient to prepare a medicine which is configured to administer to oral cavity grown with oral cancer cells so that both miR-196a and miR-196b of the sequence of antagomiR are configuring of developing medicine for curing oral cancer cells. The miR-196a has a sequence of 5′-UAGGUAGUUUCAUGUUGUUGGG-3′(SEQ.ID.NO.1). The miR-196b has a sequence of 5′-UAGGUAGUUUCCUGUUGUUGGG-3′(SEQ.ID.NO.2).
