Carol OSullivan,Gerard Michael Insley,Paul Burke,Peter V Giannoudis
申请号：
GB201607127
公开号：
GB2549714A
申请日:
2016.04.25
申请国别(地区):
GB
年份:
2017
代理人:
摘要：
An implantable device for musculo-skeletal tissue healing for bone repair and regeneration, which comprises and/or is adapted to deliver osteogenic cells, at least one osteoconductive scaffold, at least one growth factor and a favourable mechanical environment. The implant may comprise a treated collagen and/or hydrogel scaffold encapsulating a biomimetic calcium bone precursor. The implant may alternatively comprise two scaffold sponges, one adapted to hold and deliver autologous cells and the other to hold and deliver platelet rich plasma (PRP), whereby both scaffolds encapsulate a layer of biomimetic calcium designed to promote bone cell proliferation and vascularity. Preferably, the biomimetic bone precursor is octacalcium phosphate, tricalcium phosphate, hydroxyapatite, dicalcium phosphate dihydrate, amorphous calcium phosphate or calcium carbonate, most preferably octacalcium phosphate granules. The device may also deliver pharmaceutically active substances. The device may be implanted directly or delivered through a cannulated device. Also disclosed is a vascularity affinity precursor structure (VAPS) for promoting vascularization, angiogenesis, bone repair and regeneration comprising a biological layer comprising osteogenic and angiogenic cells, a biological layer comprising platelet rich plasma and an intermediate biomimetic calcium layer which provides an osteoconductive scaffold. The device may deliver all four components of the diamond concept for efficient bone repair.
