Disclosed herein is a pharmaceutical syringe having a cylindrical bore with a proximal opening the syringe comprising a distal wall of the bore defining an outlet biased from the central axis of the syringe and toward a first area of the distal wall and biased from the central axis away from a second area distinct from the first area the syringe comprising a plunger seal having a distal surface wherein when the plunger seal is fitted into the bore with the distal surface facing an inner surface of the distal wall of the bore the second area of the inner surface is axially closer to the distal surface of the plunger seal than the first area in a direction parallel to the central axis of the cylindrical bore such that fluid is expelled from the second area and towards the outlet.
