Quinn Qun Zhu;Dana M. Walters Pollak;Daniel Joseph Macool;Zhixiong Xue;Stephen K. Picataggio;Howard Glenn Damude;Peter John Gillies;James John Ragghianti;Narendra S. Yadav;Hongxiang Zhang
发明人:
Howard Glenn Damude,Peter John Gillies,Daniel Joseph Macool,Stephen K. Picataggio,Dana M. Walters Pollak,James John Ragghianti,Zhixiong Xue,Narendra S. Yadav,Hongxiang Zhang,Quinn Qun Zhu
申请号：
US12893469
公开号：
US08518674B2
申请日:
2010.09.29
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 25% eicosapentaenoic acid (EPA, an ω-3 polyunsaturated fatty acid) in the total oil fraction are described. These strains comprise various chimeric genes expressing heterologous desaturases, elongases and acyltransferases and optionally comprise various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of EPA. Production host cells are claimed, as are methods for producing EPA within said host cells.
