BARFIELD ROBYN M,BREIDENBACH MARK ALAN,DEHART GREGORY W,RABUKA DAVID
申请号：
IN5085/CHENP/2013
公开号：
IN2013CN05085A
申请日:
2013.06.28
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The present disclosure provides aldehyde tagged immunoglobulin (Ig) polypeptides that can be converted by a formylglycine generating enzyme to produce a 2 formylglycine (FGly) modified Ig polypeptide. An FGly modified Ig polypeptide can be covalently and site specifically bound to a moiety of interest to provide an Ig conjugate. The disclosure also encompasses methods of production of such aldehyde tagged Ig polypeptides FGly modified Ig polypeptides and Ig conjugates as well as methods of use of same.
