BARFIELD, ROBYN M.,BREIDENBACH, MARK ALAN,DEHART, GREGORY W.,RABUKA, DAVID
申请号：
CA2824143
公开号：
CA2824143A1
申请日:
2012.01.13
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present disclosure provides aldehyde-tagged immunoglobulin (Ig) polypeptides that can be converted by a formylglycine-generating enzyme to produce a 2-formylglycine (FGly)-modified Ig polypeptide. An FGly-modified Ig polypeptide can be covalently and site-specifically bound to a moiety of interest to provide an Ig conjugate. The disclosure also encompasses methods of production of such aldehyde-tagged Ig polypeptides, FGly-modified Ig polypeptides, and Ig conjugates, as well as methods of use of same.
