SADHU CHANCHAL,Sadhu Chanchal,DICK KEN,Dick Ken,SOWELL C. GREGORY,Sowell C. Gregory,KESICKI EDWARD A.,Kesicki Edward A.,OLIVER AMY,Oliver Amy,TREIBERG JENNIFER,Treiberg Jennifer
申请号：
SI200131039
公开号：
SI1939203T1
申请日:
2001.04.24
申请国别(地区):
SI
年份:
2015
代理人:
摘要：
Methods of inhibiting phosphatidylinositol 3-kinase delta isoform ( ) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit , while not significantly inhibiting activity of other isoforms. Compounds are provided that inhibit activity, including compounds that selectively inhibit activity. Methods of using inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using inhibitory compounds to inhibit -mediated processes in vitro and in vivo.
