COMPOSITIONS, METHODS AND USE OF SYNTHETIC LETHAL SCREENING

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专利权人:

发明人:

Myriam Heiman

申请号：

US15521780

公开号：

US20170247762A1

申请日:

2015.10.27

申请国别(地区):

US

年份:

2017

代理人:

摘要：

The present invention generally relates to methods of identifying modulators of central nervous system diseases and the use of the modulators in treatment and diagnosis. The methods utilize a novel high throughput screen that includes injection of a library of barcoded viral vectors expressing shRNAs, CRISPR/Cas systems or cDNAs into animal models of disease and detecting synthetic lethality.

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中国工程科技知识中心

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http://www.ckcest.cn/home/