BRUNNER, DANIELA,MALBERG, JESSICA,SHANKAR, BAVANI G.,KOLCZEWSKI, SABINE,LIMBERG, ANJA,PRINSSEN, ERIC,RIEMER, CLAUS,STOLL, THEODOR
申请号：
CA2883817
公开号：
CA2883817A1
申请日:
2013.09.10
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The present invention is concerned with 2-oxo-2,3-dihydro-indoles of general formula (I) wherein (N1) is phenyl or a heteroaryl group, selected from pyridinyl, pyrimidinyl, imidazolyl, isoxazolyl or pyrazolyl； (N2) is phenyl or pyridinyl, wherein the N atom in the pyridinyl group may be on all free positions； R1 is hydrogen, lower alkyl, lower alkyl substituted by halogen, lower alkoxy or halogen； n is 1 or 2； if n is 2, R1 may be the same or not； R2/R2' are independently from each other lower alkyl, or form together with the carbon atom to which they are attached a C3-6-cycloalkyl ring； R3 is lower alkyl, C3-6-cycloalkyl, CH2-C3-6-cycloalkyl, C3-6-cycloalkyl wherein one ring-carbon atom is replaced by -O-, (CH2)3-O-C3-6-cycloalkyl, lower alkyl substituted by hydroxy, lower alkyl substituted by halogen, (CH2)3-S(O)2-C3-6-cycloalkyl or (CH2)2-S(O)2-lower alkyl； R4 is hydrogen, halogen or lower alkyl； m is 1 or 2； if m is 2, R4 may be the same or not； as well as with a pharmaceutically acceptable salts thereof, with a racemic mixture, or with its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof.
