Daniela Brunner,Jessica Malberg,Bavani G. Shankar,Sabine Kolczewski,Anja Limberg,Eric Prinssen,Claus Riemer,Theodor Stoll
申请号：
US14645033
公开号：
US09221816B2
申请日:
2015.03.11
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention is concerned with 2-oxo-2,3-dihydro-indoles of general formulawhereinis phenyl or a heteroaryl group, selected from pyridinyl, pyrimidinyl, imidazolyl, isoxazolyl or pyrazolyl；is phenyl or pyridinyl, wherein the N atom in the pyridinyl group may be on all free positions；R1 is hydrogen, lower alkyl, lower alkyl substituted by halogen, lower alkoxy or halogen； n is 1 or 2； if n is 2, R1 may be the same or not；R2/R2′ are independently from each other lower alkyl, or form together with the carbon atom to which they are attached a C3-6-cycloalkyl ring；R3 is lower alkyl, C3-6-cycloalkyl, CH2—C3-6-cycloalkyl, C3-6-cycloalkyl wherein one ring-carbon atom is replaced by —O—, (CH2)3—O—C3-6-cycloalkyl, lower alkyl substituted by hydroxy, lower alkyl substituted by halogen, (CH2)3—S(O)2—C3-6-cycloalkyl or (CH2)2—S(O)2-lower alkyl；R4 is hydrogen, halogen or lower alkyl； m is 1 or 2； if m is 2, R4 may be the same or not；as well as with a pharmaceutically acceptable salts thereof, with a racemic mixture, or with its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof.
