Described herein are devices and methods for guidecatheters having one or more regions of increased flexibility. Aflexibili-ty region comprises one tubular segment of the guide catheter with anon-linear longitudinal seam between two non-concentric layers ofmate-rial having different durometers. A non-linear seam, such as a zig-zag orsinusoidal configuration, permits controlled compression of lowerdurometer material between portions of higher durometer material.
