OSMAN, TARIQ,SHILTON-BROWN (NÉE FLYNN), SHEILA BRONWEN,WRIGHT, DAVID DAKIN IORWERTH,HARMAN, ANTHONY DAVID,BOORMAN, TIMOTHY DAVID,OSMAN TARIQ,SHILTON-BROWN NÉE FLYNN SHEILA BRONWEN,WRIGHT DAVID DAKIN IORWERTH,HARMAN ANTHONY DAVID,HARMAN, ANTHONY
申请号：
ES05023679
公开号：
ES2480301T3
申请日:
2000.05.26
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A microfoam for use in sclerotherapy, comprising: a physiologically acceptable blood dispersible gas capable of dissolving or being absorbed essentially completely by blood, where the physiologically acceptable blood dispersible gas includes less than 40% by volume / volume of nitrogen and comprises at least 50% oxygen or carbon dioxide； and an aqueous sclerosant liquid suitable for use in sclerotherapy, said aqueous sclerosant liquid which is aqueous polidocanol or sodium tetradecyl sulfate； characterized in that the microfoam has a density of between 0.07 and 0.19 g / cm³ and is capable of passing through a 21 gauge needle so that 50% or more in number of its gas bubbles of at least 25 μm has 150 μm in diameter or less, and at least 95% of these bubbles are 280 μm in diameter or less； wherein the foam can be obtained by a method comprising the passage of the mixture of a physiologically acceptable blood dispersible gas and the aqueous sclerosing liquid through one or more passages having at least cross-sectional dimensions of between 0.1 and 30 μm, the ratio of gas to liquid that is controlled so that the microfoam that is produced has a density of between 0.07 g / ml and 0.19 g / ml, and a half-life of at least 2 minutes .Una microespuma para su uso en escleroterapia, que comprende: un gas dispersable en sangre fisiológicamente aceptable capaz de disolverse o ser absorbido esencialmente por completo por la sangre, donde el gas dispersable en sangre fisiológicamente aceptable incluye menos del 40 % en volumen/volumen de nitrógeno y comprende al menos el 50 % de oxígeno o dióxido de carbono； y un líquido esclerosante acuoso adecuado para su uso en escleroterapia, dicho líquido esclerosante acuoso que es polidocanol acuoso o tetradecilsulfato sódico； caracterizado porque la microespuma tiene una densidad de entre 0,07 y 0,19 g/cm³ y es capaz de atravesar una aguja de calibre 21 de manera que el 50 % o superior en número de sus burbujas de gas de al menos 25 &mu；m ti
