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Inhibiteurs de kinase régulant le signal d'apoptose
专利权人:
INC.;GILEAD SCIENCES
发明人:
申请号:
EP15151030.2
公开号:
EP2933252B1
申请日:
2010.07.12
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
The present invention relates to compounds of Formula (I): where in X1, X2, X3, X4, X5, X6, X7, X8, R1, R2, R3 are as defined above. The compounds have apoptosis signal-regulating kinase ("ASK1") inhibitory activity, and are thus useful in the treatment of ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases. The invention also relates to pharmaceutical compositions comprising one or more of the compounds of Formula (I), and to methods of preparing the compounds of Formula (I).
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