CORKEY, Britton,Graupe, Michael,Koch, Keith,Melvin, Lawrence S.,Notte, Gregory
申请号：
HK16104397.3
公开号：
HK1216426A
申请日:
2016.04.18
申请国别(地区):
HK
年份:
2016
代理人:
摘要：
The present invention relates to compounds of Formula (I): where in X1, X2, X3, X4, X5, X6, X7, X8, R1, R2, R3 are as defined above. The compounds have apoptosis signal-regulating kinase ("ASK1") inhibitory activity, and are thus useful in the treatment of ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases. The invention also relates to pharmaceutical compositions comprising one or more of the compounds of Formula (I), and to methods of preparing the compounds of Formula (I).
