A connection assembly (1) for coupling an auxiliary drive system (100) to a wheelchair (A) for disabled people, of the type comprising a fixing structure (2) adapted to be fixed to the framework (B) of the wheelchair (A) and a longitudinal member (3) operatively connected to the fixing structure (2) so that the longitudinal development axis (X-i) of the longitudinal member (3) is substantially parallel to the advancement direction (X2) of the wheelchair (A). The connection assembly comprises connection means (4) associated with the free end (31) of the longitudinal member (3) and with the auxiliary drive system (100), such connection means (4) are configured to allow rapid coupling and decoupling of the auxiliary drive system (100) to/from the wheelchair (A).
