DELUCA, HECTOR F.,PLUM, LORI A.,SICINSKI, RAFAL R.,SIBILSKA, IZABELA,CLAGETT-DAME, MARGARET
申请号：
CA2824870
公开号：
CA2824870C
申请日:
2012.06.13
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
This invention discloses 3-desoxy-2-methylene-19-nor-vitamin D analogs, andspecifically (20S)-3-desoxy-2-methylene-1 a,25-diydroxy-19-nor-vitamin D3 and(20R)-3- desoxy-2-methylene-1a,25-dihydroxy- 19-nor-vitamin D3 as well aspharmaceuticaluses therefor. These compounds exhibit relatively high binding activity andpronouncedactivity in arresting the proliferation of undifferentiated cells and inducingtheirdifferentiation to monocytes thus evidencing use as anti-cancer agentsespecially for thetreatment or prevention of osteosarcoma, leukemia, colon cancer, breastcancer, skincancer or prostate cancer. These compounds also exhibit relatively highcalcemic activityevidencing use in the treatment of bone diseases.(see formula I)
