Hector F. DeLuca,Lori A. Plum,Rafal R. Sicinski,Izabela Sibilska
申请号：
US13633975
公开号：
US08729054B2
申请日:
2012.10.03
申请国别(地区):
US
年份:
2014
代理人:
摘要：
This invention discloses 3-desoxy-2-methylene-vitamin D analogs, and specifically (20S)-3-desoxy-1α,25-dihydroxy-2-methylene-vitamin D3 and (20R)-3-desoxy-1α,25-dihydroxy-2-methylene-vitamin D3 as well as pharmaceutical uses therefor. These compounds exhibit relatively high binding activity and pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to monocytes thus evidencing use as anti-cancer agents especially for the treatment or prevention of osteosarcoma, leukemia, colon cancer, breast cancer, skin cancer or prostate cancer. These compounds also exhibit relatively high calcemic activity evidencing use in the treatment of bone diseases.
