derivatives of 3 - u0446 u0438 u043a u043b u043e u0430 u043b u043a u0438 u043b u0430 u043c u0438 u043d u043e u043f u0438 u0440 u0440 u043e u043b u0438 u0434 u0438 u043d u0430 as u0445 u0435 u043c u043e u043a u0438 u043d u043e u0432 receptor modulators

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专利权人:

Incyte Corporation

发明人:

Chu-Biao Xue,Brian Metcalf,Amy Qi Han,Darius J. Robinson,Changsheng Zheng,Anlai Wang,Yingxin Zhang

申请号：

IS8466

公开号：

IS2956B

申请日:

2006.05.15

申请国别(地区):

IS

年份:

2016

代理人:

摘要：

The present invention relates to 3-cycloalkylaminopyrrolidine derivatives of the formula I: (wherein R1, R2, R3, R4, R5, R6, R7, X, Y and Z are as defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of chemokine receptors and more specifically as modulators of the CCR2 and/or CCR5 receptor. The compounds and compositions of the invention may bind to chemokine receptors, e.g., the CCR2 and/or CCR5 chemokine receptors, and are useful for treating diseases associated with chemokine, e.g., CCR2 and/or CCR5, activity, such as atherosclerosis, restenosis, lupus, organ transplant rejection and rheumatoid arthritis.

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