CHU-BIAO XUE,BRIAN METCALF,HAO FENG,GANFENG CAO,TAISHING HUANG,CHANGSHENG ZHENG,DARIUS J. ROBINSON,AMY QI HAN
申请号：
IS7905
公开号：
IS2892B
申请日:
2005.06.22
申请国别(地区):
IS
年份:
2014
代理人:
摘要：
The present invention relates to 3-aminopyrrolidine derivatives of the formula I: (wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , X, Y and X are as defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of chemokine receptors and more specifically as a modulator of the CCR2 and/or CCR5 receptor. The compounds and compositions of the invention may bind to chemokine receptors, e.g., the CCR2 and/or CCR5 chemokine receptors, and are useful for treating diseases associated with chemokine, e.g., CCR2 and/or CCR5, activity, such as atherosclerosis, restenosis, lupus, organ transplant rejection and rheumatoid arthritis.
