The present invention discloses novel uses of specific menthol-derivativecompounds of Formula 1, and compositionsthereof, for methods of providing oral and systemic health care benefits, andmethods of up-regulating or down-regulatingperiodontal disease metabolites: Formula 1 wherein, X is an oxygen atom or anNH radical； and R is an unsubstituted or substitutedaryl or aliphatic radical. In some embodiments, the oral and systemic healthcare benefits include biofilm anti- attachment,anti-inflammation, anti-oxidant, anti-bone loss, and anti-microbial benefits.In some embodiments, the periodontal disease metabolitescorrespond to healthy and/or diseased oral status and allow differentialdiagnosis of oral health.
