NOVEL PROCESS FOR THE PREPARATION OF METHYL 2-[(3S)-[3-[(2E)-(7-CHLOROQUINOLIN-2-YL)ETHENYL]-PHENYL]-3-HALOPROPYL]BENZOATE

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专利权人:

发明人:

DR. CHAVA SATYANARAYANA,DR. GORANTALA SEETA RAMANJANEYULU,MR. INDUKURI VENKATA SUNIL KUMAR,MR. SIMHADRI SRINIVAS

申请号：

IN104/CHE/2007

公开号：

IN256088B

申请日:

2007.01.18

申请国别(地区):

IN

年份:

2013

代理人:

摘要：

Abstract The present invention relates to the novel compounds Methyl 2-[(3S)-[3-[(2E)-(7-chloro quinolin-2-yl) ethenyl] phenyl]-3-halopropyl] benzoates (IV) wherein the halo is chloro, bromo, iodo, starting from the known compound Methyl 2-[(3S)-[3-[(2E)-(7-chloroquinolin-2-yl) ethenyl] phenyl]-3-hydroxypropyl] benzoate (I). Reaction of Methyl 2-[(3S)-[3-[(2E) - (7-chloroquinolin-2-yl) ethenyl] phenyl]-3-hydroxypropyl] benzoate (I) with thionyl chloride or with methane sulfonyl chloride - lithium bromide or with trimethyl chlorosilane - sodium iodide in presence or absence of base gives Methyl 2-[(3S)-[3-[(2E)-(7-chloro quinolin-2-yl) ethenyl] phenyl]-3-halopropyl] benzoates.

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