2-3--4-4-3--1--3-- Compositions for prevention or treatment of Prion disease containing 2-3-hydroxy-4-4-3-methoxyphenoxy-1H-pyrazol-3-ylphenoxyaceto-hydrazide or pharmaceutically acceptable salts thereof as an active ingredient
The present invention relates to a process for the preparation of 2- (3-hydroxy-4- (4- (3-methoxyphenoxy) -1H-pyrazol-3-yl) phenoxy) The present invention relates to a pharmaceutical composition for the prevention and treatment of prion diseases which contains 4- (4- (3-methoxyphenoxy) -1H-pyrazol-3-yl) phenoxy) aceto-hydrazide or a pharmaceutically acceptable salt thereof as an active ingredient Specifically, it has been confirmed that the compound inhibits the formation of prion protein in a concentration-dependent manner and has no cytotoxicity, so that it can be effectively used as an active ingredient of a composition for preventing and treating prion diseases.본 발명은 2-(3-히드록시-4-(4-(3-메톡시페녹시)-1Ｈ-피라졸-3-일)페녹시)아세토-하이드라자이드[2-(3-hydroxy-4-(4-(3-methoxyphenoxy)-1H-pyrazol-3-yl)phenoxy)aceto-hydrazide] 또는 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 프리온 질환 예방 및 치료용 약학적 조성물에 관한 것으로, 구체적으로, 상기 화합물이 프리온 단백질의 침반형성을 농도의존적으로 억제하고, 세포독성이 없으므로 프리온 질환 예방 및 치료용 조성물의 유효성분으로 유용하게 사용될 수 있음을 확인하였다.
