GERRING, DAVID,HOWELL, SARAH,JEZEK, JAN,ZAKRZEWSKI, LEON
申请号：
CA3034972
公开号：
CA3034972A1
申请日:
2017.09.29
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
There is provided inter aliaan aqueous liquid pharmaceutical formulationcomprising (i) an insulincompound at a concentration of 500-1000 U/ml, (ii) ionic zinc, (iii) a zinc binding species at a concentration of 1 mM or more selected from species having a logK with respect to zinc ion binding in the range 4.5-12.3 at 25 °C, and (iv) a non- ionic surfactant and wherein the formulation is substantially free of EDTA and any other zinc binding species havinga logK with respect to zinc ion binding of more than 12.3at 25 °C.
