Jan JEZEK,David GERRING,Sarah HOWELL,Leon ZAKRZEWSKI
申请号：
US16610826
公开号：
US20200093895A1
申请日:
2018.05.03
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates inter alia to an aqueous liquid pharmaceutical formulation comprising: (i) an insulin compound； (ii) ionic zinc； (iii) a zinc binding species at a concentration of 1 mM or more selected from species having a log K with respect to zinc ion binding in the range 4.5-10 at 25° C.； (iv) a zinc binding species selected from species having a log K with respect to zinc ion binding of more than 12.3 at 25° C. at a concentration of less than about 0.3 mM； and (v) a non-ionic surfactant. It also provides related methods, uses and pharmaceutical compositions.
