The present invention relates to a compound fungus polyose with the effect of enhancing immunity. The compound is prepared with raw material as follows: Lentinus edodes 8˜100, Poria cocos 15˜100, Dictyophora indusiata 10˜200, Tremella fuciformis 15˜80, Paecilomyces hepiali mycelium 2˜50. The present invention also relates to the use of compound fungus polyose in preparing health dietary supplements for enhancing immunity. The compound fungus polyose of present invention is characterized in that it uses the edible (medicinal) fungus rich in activity polyose as the main raw material and matches various kinds of polyose components, enhances bodys immunity in multiple ways, and has beneficial health effects on those who are sub-health. The health dietary supplements prepared with compound fungus polyose of present invention as the main effective component has an evident effect on enhancing immunity and a satisfactory effect on the health of those who are sub-health.