PROBLEM TO BE SOLVED: To provide a screening method for materials/lactic acid bacteria for enhancing oral immunological tolerance, and to provide compositions based on the lactic acid bacteria.SOLUTION: This invention provides a screening method for oral immunological tolerance-enhancing materials, comprising a step of evaluating a test material that promotes the production of interferon &bgr； as an oral immunological tolerance enhancing material. This invention also provides oral immunological tolerance enhancing compositions comprising lactic acid bacterium cultures, bacterial cells of lactic acid bacteria or bacterial cell components of lactic acid bacteria as active ingredients.【課題】経口免疫寛容を増強する物質・乳酸菌のスクリーニング方法とその組成物の提供。【解決手段】本発明は、経口免疫寛容増強物質のスクリーニング方法であって、インターフェロンβの産生を促進させる被験物質を経口免疫寛容増強物質と評価する工程を含む、スクリーニング方法、及び乳酸菌の培養物、菌体または菌体成分を有効成分として含む、経口免疫寛容増強組成物、を提供する。【選択図】図１
