Disclosed herein is acollagen based pharmaceuticalcream composition essentially comprising collagen,Film former, emulsifier, anti- oxidant, amino acid, stabilizer, thickening agent, acid, moisturizing agent, preservative. The cream, maintains water content for treating wounds effectively by mimicking extra cellular matrixof slun and normalize the tissue-environment around the wound site.This composition promotes enhanced cellular activity. Specifically the composition is able to stimulate the fibroblast growth and proliferation and thereby facilitates the collagen production in wounded tissue. This invention promotes wound healing and has application in wound care management and drug delivery.