A clamp 1 for securing a medical tube inserted into a patients body. Clamp 1 comprises: a clamp body defining an opening 6 for accommodating the medical tube; an outer portion 13; and a sealing element 14 to engage with the medical tube and thereby forming a seal around the external surface of the medical tube. Clamp 1 may comprise a fastener to fasten the clamp 1 to the patient. The sealing element 14 and outer portion 13 may be provided with a channel that extends from an outermost edge of the outer portion 13 relative to the sealing element 14 to the opening 6 defined by the sealing element 14, where the medical-tube can pass through the channel. The channel may have open and closed configurations. Outer portion 13 may comprise two components 2 that are moveable relative to one another between open and closed positions and where the components 2 may be hinged together and where the clamp 1 may be provided with a catch 10 for holding it in a closed position. Clamp 1 may be used in combination with a wound dressing. Described as applicable in clamping medical drain tubes, such as a chest drain tube.