Anisul Quadir;Rebecca Ham Scheper;Rudolph Ernest Lisa;Peter Grzesowski
发明人:
Rudolph Ernest Lisa,Anisul Quadir,Rebecca Ham Scheper,Peter Grzesowski
申请号：
US10999580
公开号：
US09149433B2
申请日:
2004.11.30
申请国别(地区):
US
年份:
2015
代理人:
摘要：
A method for formation of micro-prilled poloxamer particles is disclosed. The particles find special use in pharmaceutical formulations. The process involves use of atomizing nozzles at higher than normal pressure atomizing gas, high atomizing gas temperature, use of high feed temperatures to reduce the viscosity of the poloxamer and optionally sieving after prill formation in prilling towers. The poloxamer particles are spherical and preferably have an average nominal diameter of less than or equal to 106 microns. The process is very cost effective and rapid.
