Method for preparing a cell, and/or tissue and/or disease-stage specific pharmaceutical (A). Method for preparing a cell, and/or tissue and/or disease-stage specific pharmaceutical (A) comprises: (a) identifying an RNA (I) the expression of which in a target cells differs from that in a control cell； (b) designing a specific RNA (II) that binds to (I) and functionally inactivates it； (c) applying (II) to target cells； and (d) formulating (II) and/or the target cells of (c) into a pharmaceutical. Independent claims are also included for the following: (1) DNAzyme (IIIa) that cleaves GATA-3 mRNA specifically； and (2) DNAzyme (IIIb) that cleaves T-bet mRNA specifically. ACTIVITY : Antiinflammatory； Immunosuppressive； Antirheumatic； Antiallergic； Antiasthmatic； Antiarteriosclerotic； Antipsoriatic； Dermatological. No details of tests for these activities are given. MECHANISM OF ACTION : RNA interference； DNAzyme. Inactivation of transcription factors or signal-transduction molecules by RNA cleavage.
