Piet HERDEWIJN,Steven DE JONGHE,Shrivinas DUMBRE,Chao LIU
申请号：
US15568692
公开号：
US20180105552A1
申请日:
2016.04.27
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to novel pro-drugs of L-2′-deoxythreose nucleoside phosphonates, such as phosphoramidate, phosphorodiamidate and phospho-diester pro-drugs. The invention also relates to a process for preparing these novel prodrugs of nucleoside phosphonates. The invention also relates to the use of these novel phosphonate-modified nucleosides to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infections, particularly infections with viruses belonging to the HBV family.
