Fibrinogen preparation enriched for fibrinogen with extended alpha chain

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专利权人:

プロフィブリックス ビーブイ

发明人:

グリムベルゲン，ヨセフ,コープマン，ヤコブ,バウト，アブラハム,グリムベルゲン,ヨセフ,コープマン,ヤコブ,バウト,アブラハム

申请号：

JP2012547516

公开号：

JP5960606B2

申请日:

2011.01.07

申请国别(地区):

JP

年份:

2016

代理人:

摘要：

The present invention relates to fibrinogen preparations enriched in &alpha；-extended fibrinogen. Compositions comprising such preparations show improved clotting properties compared to preparations based on HMW Fib which typically contain no or only low amounts of &alpha；-extended fibrinogen. In particular, clot formation time and the clot strength of a clot made by &alpha；-extended fibrinogen are improved. In addition, plasmin-mediated degradation of &alpha；-extended fibrinogen is reduced as compared to plasma derived fibrinogen.

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