Pharmaceutically active isoindoline derivatives

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专利权人:

Celgene Corporation

发明人:

Hon-Wah Man,George W. Muller

申请号：

US14046779

公开号：

USRE045685E1

申请日:

2013.10.04

申请国别(地区):

US

年份:

2015

代理人:

摘要：

Isoindolin-1-one and Isoindoline-1,3-dione substituted in the 2-position with an α-(3,4-disubstituted phenyl)alkyl group and in the 4- and/or 5-position with a nitrogen-containing group are inhibitors of, and thus useful in the treatment of disease states mediated by, TNFα and phosphodiesterase. A typical embodiment is 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4,5-diaminoisoindoline-1,3-dione.

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