PHARMACEUTICALLY ACTIVE ISOINDOLIN DERIVATIVES

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专利权人:

CELGENE CORPORATION

发明人:

MAN, HON-WAH,MULLER, GEORGE W.

申请号：

AT10176390

公开号：

AT544451T

申请日:

2000.11.09

申请国别(地区):

AT

年份:

2012

代理人:

摘要：

Isoindolin-1-one and Isoindoline-1, 3-dione substituted in the 2-position with an alpha -(3, 4-disubstituted phenyl)alkyl group and in the 4- and/or 5-position with a nitrogen-containing group are inhibitors of, and thus useful in the treatment of disease states mediated by, TNF alpha and phosphodiesterase. A typical embodiment is 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4,5-diaminoisoindoline-1,3-dione.

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