Dow Global Technologies LLC;Rohm and Haas Company;Regents of the University of Minnesota
发明人:
Swapnil Tale,Theresa M. Reineke,Frank S. Bates,Jeffrey M. Ting,Lakmini Widanapathirana,Steven J. Guillaudeu,Li Guo
申请号：
US15554442
公开号：
US20180066091A1
申请日:
2016.02.24
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to the use of uncrosslinked copolymers having a backbone comprising i) a plurality of thermo-responsive structural units derived from one or more than one N-alkyl or N,N-dialkyl substituted (alkyl)acrylamide monomer and ii) a plurality of hydrophilic structural units derived from one or more than one second ethylenically unsaturated monomer as excipients in solid mixtures with poorly water-soluble substances for effective solubilization of the latter in aqueous media. Solid dosage forms comprising a solid mixture of such copolymer(s) and poorly water-soluble substance(s) are also within the scope of the invention.
