Zmodyfikowane w pozycji 6 analogi bicykliczne kwasów nukleinowych

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专利权人:

Inc.;Isis Pharmaceuticals

发明人:

SWAYZE, ERIC E.,SETH, PUNIT P.

申请号：

PL10176867

公开号：

PL2314594T3

申请日:

2007.01.27

申请国别(地区):

PL

年份:

2014

代理人:

摘要：

The present invention provides 6-modified bicyclic nucleoside analogs and oligomeric compounds comprising these nucleoside analogs. In preferred embodiments the nucleoside analogs have either ( R ) or ( S )-chirality at the 6-position. These bicyclic-nucleoside analogs are useful for enhancing properties of oligomeric compounds including nuclease resistance.

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