Pharmaceutical compositions with resistance to soluble CEA - comprising antibodies that bind to CD3 and CEA

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专利权人:

MICROMET AG

发明人:

LUTTERBUSE, RALF,MAYER, PETRA,SCHALLER, EVELYNE,RAU, DORIS,MANGOLD, SUSANNE,KUFER, PETER,MURR, ALEXANDER,WISSINGER, MONIKA,RAUM, TOBIAS

申请号：

NZ56920406

公开号：

NZ569204A

申请日:

2006.12.21

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

Disclosed is a bispecific single chain antibody which has (a) a first binding domain specifically binding to human CD3, and (b) a second binding domain specifically binding to human CEA. The antibody is adapted for the treatment of progressive tumors, late stage tumors, tumor patients with high tumor load/burden, metastatic tumors, or tumor patients with a CEA serum concentration higher than 100 ng/ml.

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