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Pharmaceutical compositions with resistance to soluble CEA
专利权人:
AMGEN RESEARCH (MUNICH) GMBH
发明人:
LUTTERBUSE, RALF,MAYER, PETRA,SCHALLER, EVELYNE,RAU, DORIS,MANGOLD, SUSANNE,KUFER, PETER,MURR, ALEXANDER,WISSINGER, MONIKA,RAUM, TOBIAS
申请号:
AU2011204778
公开号:
AU2011204778B2
申请日:
2011.07.14
申请国别(地区):
AU
年份:
2013
代理人:
摘要:
Abstract The present invention relates to pharmaceutical compositions for the treatment of an 5 epithelial tumor in a human, said pharmaceutical composition comprising a bispecific single chain antibody which has a first binding domain specifically binding to human CD3, and a second binding domain specifically binding to human CEA, wherein said second binding domain comprises at least a part of the CDR-H3 or the complete CDR-H3 of murine monoclonal antibody A5B7. Furthermore, processes for the 10 production of said pharmaceutical compositions as well as medical/pharmaceutical uses for the specific bispecific single chain antibody molecules bearing specificities for the human CD3 antigen and the human CEA antigen are disclosed. 273985_1 (GHMatter) P78101 AU 1
来源网站:
中国工程科技知识中心
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