Aspects of positioning devices, methods, and systems are disclosed. An exemplary method comprises: moving a distal end of a tube into a body, the tube including a lumen and a shaft in the lumen, the shaft having a transducer； sending a first signal to the transducer； passing, with the transducer, in response to the first signal, a wave energy into the body； receiving, with the transducer, a reflected portion of the wave energy； generating, with the transducer, a second signal in response to the reflected portion of the wave energy； determining, with a processor, an indicia of the body in response to the second signal； and identifying, with the indicia, a targeted issue in the body； positioning the distal end of the tube at the targeted tissue in response to the indicia； and removing a portion of the targeted tissue with the distal end of the tube.
