PROBLEM TO BE SOLVED: To provide a new compound having a wrinkle-ameliorating effect.SOLUTION: There are provided a compound represented by the formula (5), a stereoisomer thereof or a pharmacologically acceptable salt thereof. [R15 represents H or a linear or branched alkyl group having 1 to 8 carbon atoms； R16 represents -SO3H or -SO2-X4； X4 represents H or a substituted or unsubstituted aliphatic hydrocarbon group having 1 to 8 carbon atoms in which H or C is a heteroatom； R17 represents H or an acyl group having a linear or branched alkyl chain having 1 to 8 carbon atoms； R18 represents a phenyl group, an ethylphenyl group, a propylphenyl group, a butylphenyl group, a pentylphenyl group, a hexylphenyl group or the like； m represents 0； n represents an integer of 1 or 2.]【課題】シワ改善効果を有する新規の化合物を提供する。【解決手段】式（５）で表される化合物、その立体異性体、又はそれらの薬理学的に許容される塩。［Ｒ15はＨ又はＣ１～８の直鎖／分岐のアルキル基；Ｒ16は－ＳＯ3Ｈ、又は－ＳＯ2－Ｘ4；Ｘ4はＨ又はＣが複素原子で置換／非置換のＣ１～８の脂肪族炭化水素基等；Ｒ17はＨ又は炭素数１～８の直鎖／分岐のアルキル鎖を有するアシル基；Ｒ18はフェニル基、エチルフェニル基、プロピルフェニル基、ブチルフェニル基、ペンチルフェニル基、ヘキシルフェニル基等；ｍは０；ｎは１又は２の整数]【選択図】図３
