BELL, MICHAEL GREGORY,HOOGESTRAAT, PAUL J.,MABRY, THOMAS EDWARD,SHEN, QUANRONG,ESCRIBANO, ANA MARIA
申请号：
PE2013002810
公开号：
PE20140606A1
申请日:
2012.06.07
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
It refers to a compound from pyrazole, where n is 0 or 1； m is 1 or 2； R1 and R2 are h-ch3 or ch2ch3； R3 is h, Cl, CN, etc.； R4 is f, Cl, Br, CH3 or OCH3. The preferred compounds are: 4 - (6,6-dimethyl-4,5-dihydro-cyclopentyl (c) pyrazol-4-il)； 4 - (6,6-dimethyl-4,5-dihydro-1h-cyclopentyl (c) pyrazol-4-il) - 3-fluorobenzoate； 4 - (4-chloro-3-fluoroffenil) - 6-dimethyl-1,4,5,6-tetrahydropropylketone； others. He also mentioned a pharmaceutical composer These compounds are aseptic aldehyde inhibitors that can be used to treat diabetic nephropathy and chronic kidney disease.SE REFIERE A COMPUESTOS DERIVADOS DE PIRAZOL DE FORMULA (I) DONDE n ES 0 O 1； m ES 1 O 2； R1 Y R2 SON CADA UNO H, -CH3 O -CH2CH3； R3 ES H, Cl, CN, ENTRE OTROS； R4 ES F, Cl, Br, -CH3 O -OCH3. SON COMPUESTOS PREFERIDOS: 4-(6,6-DIMETIL-4,5-DIHIDRO-1H-CICLOPENTA[c]PIRAZOL-4-IL)BENZONITRILO； 4-(6,6-DIMETIL-4,5-DIHIDRO-1H-CICLOPENTA[c]PIRAZOL-4-IL)-3-FLUORO-BENZONITRILO； 4-(4-CLORO-3-FLUOROFENIL)-6,6-DIMETIL-1,4,5,6-TETRAHIDROCICLOPENTA[c]PIRAZOL； ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE ALDOSTERONA SINTASA SIENDO UTILES EN EL TRATAMIENTO DE NEFROPATIA DIABETICA, ENFERMEDAD RENAL CRONICA
