BELL, MICHAEL GREGORY,HOOGESTRAAT, PAUL J.,MABRY, THOMAS EDWARD,SHEN, QUANRONG,ESCRIBANO, ANA MARIA
申请号：
PE0028102013
公开号：
PE06062014A1
申请日:
2012.06.07
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Refers to Derivatives of pyrazole compounds of formula (i) wherein n is 0 OR 1 and M is 1 or 2 R1 and R2 are each h, CH3 or - CH2CH3 R3 is H, CL, CN, among others R4 is F, CL, BR, or - CH3 OCH3.Preferred compounds are: 4 - (6,6 Dimethyl 4,5-dihydro - cyclopenta [c] - 1H pyrazole - 4-yl) benzonitrile 4 - (6,6 Dimethyl 4,5-dihydro - cyclopenta [c] - 1H pyrazole - 4-yl) - 3 - fluoro Benzonitrile 4 - (4 - chlorine - 3-fluorophenyl) - 6,6 Dimethyl 1,4,5,6 - tetrahidrociclopenta [c] pyrazole among others. It also relates to a Pharmaceutical composition.These compounds are useful as aldosterone synthase inhibitors in the treatment of diabetic nephropathy, Chronic Kidney DiseaseSE REFIERE A COMPUESTOS DERIVADOS DE PIRAZOL DE FORMULA (I) DONDE n ES 0 O 1 m ES 1 O 2 R1 Y R2 SON CADA UNO H, -CH3 O -CH2CH3 R3 ES H, Cl, CN, ENTRE OTROS R4 ES F, Cl, Br, -CH3 O -OCH3. SON COMPUESTOS PREFERIDOS: 4-(6,6-DIMETIL-4,5-DIHIDRO-1H-CICLOPENTA[c]PIRAZOL-4-IL)BENZONITRILO 4-(6,6-DIMETIL-4,5-DIHIDRO-1H-CICLOPENTA[c]PIRAZOL-4-IL)-3-FLUORO-BENZONITRILO 4-(4-CLORO-3-FLUOROFENIL)-6,6-DIMETIL-1,4,5,6-TETRAHIDROCICLOPENTA[c]PIRAZOL ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE ALDOSTERONA SINTASA SIENDO UTILES EN EL TRATAMIENTO DE NEFROPATIA DIABETICA, ENFERMEDAD RENAL CRONICA
