NICK KNUDSEN,JASON PINKSTAFF,VADIM KRAYNOV,AMHA HEWET,KRISTINE DE DIOS,LORRAINE SULLIVAN
申请号：
PT11818758
公开号：
PT2605789T
申请日:
2011.08.17
申请国别(地区):
PT
年份:
2019
代理人:
摘要：
Modified relaxin polypeptides and uses thereof are provided. In particular, modified relaxin polypeptide variants having substitutions with a non-naturally encoded amino acid in the A or B chain, especially residues 1, 5, 13, 18 and B chain residue 7. The non-natural amino acid is preferably a phenylalanine analog, especially para-acetyl-phenylalanine (pAcF or pAF). The relaxin variants are linked to compounds to improve their pharmacological properties, especially PEG having an average MW of between about 5 kDa and about 40 kDa , which is linked to the non-naturally encoded amino acid.
